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MAO inhibitors

Normally DMT, found in plants such as Mimosa hostilis, Diplopterys cabrerana, Desmanthus illinoensis, Psychotria viridis and Phalaris arundinacea, is not effective when ingested orally. This is because it is broken down in the body by monoamine oxydase (MAO). MAO is an important enzyme that breaks down certain chemical compounds such as drugs and poisons.

MAO inhibitors interfere with the action of the MAO enzyme and stop the breakdown of chemical compounds such as DMT, making it effective when ingested orally. This is the underlying principle of the traditional visionary Amazone medicin Ayahuasca.

In the right proportions, hallucinogenic mushrooms and some other psychedelics can also be used safely in conjunction with MAOIs. By combining them with an MAOI the trip will last longer and become more intense.

MAOIs must be used with great caution, because they cause otherwise harmless food to become poisonous. The results can be dangerous: headaches, nausea, even unconsciousness and death. In shamanic tradition MAOIs are used typically after at least one day of fasting, or another form of intense dietary restriction. It is advised to follow this tradition.

List of substances

Below is a list of substances that you should NOT take 12 hours before and 12 hours after taking an MAOI.

Very dangerous antidepressants containing Selective Serotonine Reuptake Inhibitors (SSRIs) such as the herb Kanna (Sceletium tortuosum) and pills such as paroxetine (Seroxat), fluoxetine (Prozac), citalopram (Cipramil), fluvoxamine (Fevarin) and sertraline (Zoloft)
sleeping-pills
anaesthetics
migraine medicines
allergy medicines
over the counter cold medicines
cocaine
amphetamines (speed)
MDMA (XTC)
mescaline cacti (peyote and san pedro)
alcohol
ephedra/ephedrine (for example in products such as Ephedra Super caps, Super Stacker, Xtenzion)
pseudoephedrine
macromerine
phentermine
Can cause headaches or sickness cultured dairy products (buttermilk, yogurt, and sour cream)
all aged/mature cheese (exception: cottage cheese, cream cheese)
dry and fermented sausage (bologna, salami, pepperoni, corned beef, and liver)
all meat, fish and eggs which are not fresh
pickled herring and salted dried fish
meat extracts
yeast extracts/brewer's yeast (Marmite)
sauerkraut
fruits (bananas, avocados, canned figs, raisins, red plums, pine-apple, raspberries)
nuts (peanuts)
broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans)
soyasauce
LSA (morning glory and baby hawaiian woodrose)
MDA related herbs (nutmeg, sweet flag)
chocolate
caffeine (coffee, tea, cola, guarana, energy drinks)
ginseng
St Johns wort
nasal sprays (Vicks Sinex, Prevalin of Otrivin)
other MAO inhibitors

The following substances are MAOIs

Syrian Rue (Peganum harmala), Banisteriopsis caapi, Passionflower, Yohimbe and certain anti-depressants.


More information

Read the encyclopedia article "MAOIs" for more information and a full list of MAOIs and foods to avoid.
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